ParkinsonCanadaV1, Main, Exploration, bibRecord, 001211

Impaired executive function signals in motor brain regions in Parkinson's disease.

Identifieur interne : 001211 ( Main/Exploration ); précédent : 001210; suivant : 001212

Impaired executive function signals in motor brain regions in Parkinson's disease.

Auteurs : Ian G M. Cameron [Canada] ; Giovanna Pari ; Nadia Alahyane ; Donald C. Brien ; Brian C. Coe ; Patrick W. Stroman ; Douglas P. Munoz

Source :

NeuroImage [ 1095-9572 ] ; 2012.

RBID : pubmed:22270353

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex (physiopathology), Parkinson Disease (physiopathology), Saccades.
MESH :
- physiopathology : Motor Cortex, Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Saccades.

Abstract

Recent evidence has shown that patients with Parkinson's disease (PD) often display deficits in executive functions, such as planning for future behavior, and these deficits may stem from pathologies in prefrontal cortex and basal ganglia circuits that are critical to executive control. Using the antisaccade task (look away from a visual stimulus), we show that when the preparatory 'readiness' to perform a given action is dissociated from the actual execution of that action, PD patients off and on dopamine medication display behavioral impairments and reduced cortical brain activation that cannot be explained by a pathology related to dysfunction in movement execution. Rather, they show that the appropriate task set signals were not in place in motor regions prior to execution, resulting in impairments in the control of subsequent voluntary movement. This is the first fMRI study of antisaccade deficits in Parkinson's disease, and importantly, the findings point to a critical role of the basal ganglia in translating signals related to rule representation (executive) into those governing voluntary motor behavior.

DOI: 10.1016/j.neuroimage.2012.01.057
PubMed: 22270353

Affiliations:

Canada

Le document en format XML

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<front><div type="abstract" xml:lang="en">Recent evidence has shown that patients with Parkinson's disease (PD) often display deficits in executive functions, such as planning for future behavior, and these deficits may stem from pathologies in prefrontal cortex and basal ganglia circuits that are critical to executive control. Using the antisaccade task (look away from a visual stimulus), we show that when the preparatory 'readiness' to perform a given action is dissociated from the actual execution of that action, PD patients off and on dopamine medication display behavioral impairments and reduced cortical brain activation that cannot be explained by a pathology related to dysfunction in movement execution. Rather, they show that the appropriate task set signals were not in place in motor regions prior to execution, resulting in impairments in the control of subsequent voluntary movement. This is the first fMRI study of antisaccade deficits in Parkinson's disease, and importantly, the findings point to a critical role of the basal ganglia in translating signals related to rule representation (executive) into those governing voluntary motor behavior.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Impaired executive function signals in motor brain regions in Parkinson's disease.

Impaired executive function signals in motor brain regions in Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.